Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C2 All Species: 23.64
Human Site: S189 Identified Species: 43.33
UniProt: Q9UKV8 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKV8 NP_001158095.1 859 97208 S189 F T A S E G C S N P L G G G R
Chimpanzee Pan troglodytes XP_001142838 813 92351 L169 P S L W K M M L N I D V S A T
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 S381 F T A S E G C S N P L G G G R
Dog Lupus familis XP_532338 899 101246 S229 F T A S E G C S N P L G G G R
Cat Felis silvestris
Mouse Mus musculus Q8CJG0 860 97305 S190 F T A S E G C S N P L G G G R
Rat Rattus norvegicus Q9QZ81 860 97300 S190 F T A S E G C S N P L G G G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513588 873 98974 S203 F T A S E G C S N P L G G G R
Chicken Gallus gallus Q5ZLG4 860 97253 D190 F S A P E G Y D H P L G G G R
Frog Xenopus laevis Q6DCX2 862 97626 A192 F T A S E G C A N P L G G G R
Zebra Danio Brachydanio rerio A3KPK0 860 97313 D190 F S S P E G Y D H P L G G G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 N563 F K M S D P N N R H E L D D G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 Y259 Y T W K S S C Y R I P T A A G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 K348 Y S P D I G K K Q S L G D G L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 80.2 95.3 N.A. 98.9 99 N.A. 97.1 79.7 96.1 79.4 N.A. 22.4 N.A. 33.4 N.A.
Protein Similarity: 100 94.6 81 95.3 N.A. 99 99.3 N.A. 97.5 89.3 98.2 89.4 N.A. 36.4 N.A. 51.5 N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. 100 66.6 93.3 60 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 80 100 80 N.A. 26.6 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 37.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 53.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 62 0 0 0 0 8 0 0 0 0 8 16 0 % A
% Cys: 0 0 0 0 0 0 62 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 8 0 0 16 0 0 8 0 16 8 0 % D
% Glu: 0 0 0 0 70 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 77 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 77 0 0 0 0 0 77 70 77 16 % G
% His: 0 0 0 0 0 0 0 0 16 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 16 0 0 0 0 0 % I
% Lys: 0 8 0 8 8 0 8 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 8 0 0 0 0 8 0 0 77 8 0 0 8 % L
% Met: 0 0 8 0 0 8 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 8 62 0 0 0 0 0 0 % N
% Pro: 8 0 8 16 0 8 0 0 0 70 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 16 0 0 0 0 0 70 % R
% Ser: 0 31 8 62 8 8 0 47 0 8 0 0 8 0 0 % S
% Thr: 0 62 0 0 0 0 0 0 0 0 0 8 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 0 0 0 0 16 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _